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Pineapple Express is a sativa-dominant hybrid marijuana strain made by crossing Trainwreck with Hawaiian. While this strain rose to fame on the silver screen in 2008 amidst the release of Pineapple Express, it is a real strain that you can find on the shelves of dispensaries across the country. Since then, this strain has become a favorite in the hearts and minds of cannabis lovers. Pineapple Express produces long-lasting energetic effects that you can feel right away.